A. Faktor

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Faktor sigma je podjednotka bakteriálnych DNA-závislých RNA polymeráz, ktorá umožňuje počiatočnú fázu (iniciáciu) transkripcie a výber promótoru. Každá bakteriálna RNA polymeráza sa pred vlastným procesom transkripcie musí nadviazať na faktor sigma a vzniknutý komplex prisadne na promótor na vlákne DNA. Keď dosiahne veľkosť vzniknutej RNA asi 8 – 10 nukleotidov, tento RNA reťazec spôsobí disociáciu (vyviazanie) faktora sigma. Po dokončení transkripcie vlákna sa RNA polymeráza uvoľní do cytosólu a opäť môže nadviazať nový sigma faktor.

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